The effectiveness of HBOT on the disease, called aging

When we speak about aging, we do not speak only about wrinkles and gray hair. At certain point in our lives the organs start to decline in function. The heart needs to work harder to pump blood through stiffened blood vessels and arteries. Bones shrink in size and density; they are more susceptible to fracture. We are in fact shorter. The bladder becomes less elastic, which means that we need to urinate more. We start forgetting things. Our memory is not working as it has. Our skin is less elastic. Etc.

We are getting older, if we want or not. But it would be great if we can renew the organ function, to memorize everything as we use to do, to fully live our lives and do all the things that we used to do.

Insights from Dr. Shai Efrati

Dr. Shai Efrati from Faculty of Medicine and Sagol School of Neuroscience from Israel explains how we can reverse the aging and rejuvenate. Dr. Efrati is asking, how can a salamander grow another leg? With stem cells and supporting environment, t.i. oxygen., dr. Efrati says. Humans can do this by hyperbaric oxygen therapy (HBOT).

In hyperbaric chamber we increase the blood concentration of the oxygen, the oxygen needed for the regenerative process. HBOT utilizes 100% oxygen in an environmental pressure higher than one absolute atmospheres (ATA) to enhance the amount of oxygen dissolved in body’s tissues.

(Source of Dr. Shai Efrati portrait: https://aviv-clinics.com/about/shai-efrati/)

HBOT is able to reverse telomere shortening and accumulation of damaged senescent cells

There are many studies already published showing that we can improve the cognitive functions of humans with HBOT, now the researchers have also shown how to reverse two main indicators of biological aging with HBOT.

The Israeli group of scientists from Tel Aviv University and The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center have done the incredible thing, they reversed the aging with the simple non-invasive treatment, hyperbaric oxygen therapy. “Scientists have shown that this treatment was able to reverse two main indicators of biological aging – telomere shortening and accumulation of damaged senescent cells.” Until now we have only known that lifestyle factors may affect the health and lifespan of an individual by affecting telomere length. This is the first study ever that shows the effectiveness of hyperbaric oxygen therapy on the disease, called aging.

Telomeres: Guardians of genome health

Telomeres are the specific DNA protein structures found at both ends for each chromosome. They protect the genome from nucleolytic degradation, unnecessary recombination, repair, and interchromosomal fusion. Telomers play a vital role in preserving information in our genome.

Telomere length shortens with age. Telomere length in humans seems to decrease at a rate of 24.8–27.7 base pairs per year. Telomere length, shorter than the average telomere length for a specific age group, has been associated with increased incidence of age-related diseases and/or decreased lifespan in humans.

Telomere length is affected by a combination of factors including donor age, genetic, epigenetic make-up and environment, social and economic status, exercise, body weight, and smoking. Gender does not seem to have any significant effect on the rate of telomere loss.

Telomere Length and Cellular Senescence

When telomere length reaches below a critical limit, the cells undergo senescence and/or apoptosis. Cell senescence is caused by the activation of cell cycle inhibition pathways induced by an accumulation of cellular damage, where cells permanently leave the cell cycle. Senescent cells undergo changes in cell morphology, transcription, protein homeostasis, metabolism and other characteristic alterations. At the same time, senescent cells are able to resist apoptosis and accumulate in multiple organs and tissues in vivo.

Senescent cells are capable of activating inflammatory factor secretion pathways, generating local, non‑infectious inflammatory microenvironments within tissues, leading to organ degeneration and the development of aging‑associated diseases.

HBOT extends telomeres significantly in 3 months

Dr. Amir Hadanny, co-author of the study explained: “What is remarkable to note in our study, is that in just three months of HBOT, we were able to achieve such significant telomere elongation – at rates far beyond any of the current available interventions or lifestyle modifications. With this pioneering study, we have opened a door for further research on the prolonged cellular impact of HBOT to reverse the aging process.”

The study from Israeli researches is a breakthrough that opened a new grounding for researchers. Now can actually measure the effectiveness of HBOT on human body. The findings are bringing a new hope for us and offered a new prospective: we can live longer, healthier and more productive with hyperbaric oxygen therapy. As Dr. Efrati says, we need to start using it early, when we are still functioning, still have some tissues to repair.

(Figure 3 source: https://www.aging-us.com/article/202188/text)

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